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Cytokeratin 5 (KRT5)
英文名：Rabbit Monoclonal Antibody
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| 貨號 | 規格 | 貨期 | 庫存 | 價格 | 促銷價 | 訂購 |
| 1308113489-100ul | 現貨 | 0 | ￥0 |
| 別 名 | KRT5 antibody, CK5 antibody, DDD antibody, EBS2 antibody, K5 antibody, KRT5A antibody, Keratin, type II cytoskeletal 5 antibody, Type-II keratin Kb5 antibody |
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| 產品參數 | 【產品介紹】Keratins are cytoplasmic intermediate
filament proteins expressed by epithelial cells. The mitotically active basal layers of most stratified squamous epithelia express 10 to 30% of their total protein as keratin. The two keratins specifically expressed in these cells are the type II keratin CK-5 and its corresponding partner, type I keratin CK-14, both of which are essential for the formation of 8-nm filaments (1). CK-5 and calretinin have been useful in different studies as immunohistochemical markers suggestive of mesothelioma, and their expression is analyzed for the histological differential diagnosis with adenocarcinomas, especially when confronting with metastatic tumors of unknown origin (2). Loss-of-function mutations in the keratin 5 gene (KRT5) affected family members and in six unrelated patients with Dowling-Degos disease (DDD), an autosomal dominant genodermatosis. This suggests a crucial role for keratins in the organization of cell adhesion, melanosome uptake, organelle transport, and nuclear anchorage (3). Recommended Applications WB, IHC, ICC, IP Applications and Recommended Dilution Factors WB: 1:10,000 IHC: 1:100 ICC: 1:250 IP: 1:60 Species Reactivity * Human *Cross reactivity determined by western blot only. Products Data A. Western blot analysis on A431 cell lysate using anti-CK-5 RabMAb (cat. # 2290-1), dilution 1:10,000. B. Immunohistochemical analysis of paraffin-embedded human squamous cervical carcinoma using anti-CK-5 RabMAb (cat.#2290-1). Specificity A synthetic peptide corresponding to residues in the head region of human cytokeratin 5 was used as an immunogen. |
| 性狀 | 【反應特異性】Human
【克隆 ID】EPR1600Y 【用途】WB , IHC , ICC , IP 【抗原分子量】59kDa |
| 貯存 | Storage Condition and Buffer Store at -20 °C. Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt. |
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