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ERG DyLight? 488
英文名：Rabbit Monoclonal Antibody
Cas號(hào)：
Cas號(hào)：
檢測(cè)信息查詢
| 貨號(hào) | 規(guī)格 | 貨期 | 庫存 | 價(jià)格 | 促銷價(jià) | 訂購 |
| 1308113560-100ul | 現(xiàn)貨 | 0 | ￥0 |
| 別 名 | ERG antibody, erg-3 antibody, p55 antibody, Transcriptional regulator ERG antibody, Transforming protein ERG antibody |
| Cas號(hào) | |
| M D L | |
| 分子式 | |
| 分子量 | |
| 產(chǎn)品參數(shù) | 【產(chǎn)品介紹】Transcriptional Regulator ERG belongs to the
ETS family that is involved in the regulation of a wide variety of cellular and developmental processes (1). This family of transcription factors contains approximately 30 members that share a highly conserved DNA-binding domain (ETS domain) (2, 3) and differs from each other in other domains (such as absence or presence of the Pointed/SAM domain) and are thus distinguished in sub-families (1). ERG belongs to the Erg/Fli-1 sub-family. It has been widely studied for its involvement in human cancers; TMPRSS2-ERG fusion, which occurs on account of translocations and interstitial deletions, is implicated in aggressive forms of prostate cancer (4, 5). ERG is linked to normal processes such as mesoderm formation and is found to form functional complexes with Jun/Fos, with the resulting ternary complexes regulating expression of genes such as metalloprotease-1 (MMP-1) and MMP-3 (1). It may also participate in transcriptional regulation through the recruitment of SETDB1 histone methyltransferase and subsequent modification of local chromatin structure (2). Recommended Applications ICC Applications and Recommended Dilution Factors ICC: 1:50 - 100 Species Reactivity Human Products Data Immunofluorescent analysis of LnCaP cells using anti-ERG RabMAb (DyLight? 488 conjugate, cat.# 4583-1) (green) and dapi (blue). Specificity A synthetic peptide corresponding to residues on the C-terminus in human ERG was used as an immunogen. This antibody also detects Fli-1. |
| 性狀 | 【反應(yīng)特異性】Human
【克隆 ID】EPR3864 【用途】ICC 【抗原分子量】55kDa |
| 貯存 | Storage Condition and Buffer Store at 2-8° C. PBS (pH 7.2), 0.02% sodium azide, 0.05% BSA. Protect from light. Stable for 6 months from date of receipt. |
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