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FE65 (APBB1)
英文名：Rabbit Monoclonal Antibody
Cas號(hào)：
Cas號(hào)：
檢測(cè)信息查詢
| 貨號(hào) | 規(guī)格 | 貨期 | 庫(kù)存 | 價(jià)格 | 促銷價(jià) | 訂購(gòu) |
| 1308113581-100ul | 現(xiàn)貨 | 0 | ￥0 |
| 別 名 | APBB1 antibody, FE65 antibody, MGC:9072 antibody, RIR antibody, Amyloid beta A4 precursor protein-binding family B member 1 antibody, Protein Fe65 antibody |
| Cas號(hào) | |
| M D L | |
| 分子式 | |
| 分子量 | |
| 產(chǎn)品參數(shù) | 【產(chǎn)品介紹】Amyloid beta A4 precursor protein-binding
family B member 1 (FE65) is a member of a family of multidomain adaptor proteins (FE65, FE65L1, and FE65L2) that form multiprotein complexes with a range of functions. FE65 is highly expressed in the brain and it has three protein-protein interaction domains: a WW domain and two PID/PTB domains. Through the PTB2 domain, FE65 interacts with the Alzheimer’s disease amyloid precursor protein (APP) intracellular domain (AICD) and can alter APP processing. The WW domain is responsible for the interaction with various proteins, which in turn interacts with the cytoskeleton. The second PID/PTB domain of FE65 binds to the transcription factor, CP2/LSF/LBP1 protein (1, 2). FE65 also plays a central role in the response to DNA damage by translocating to the nucleus and inducing apoptosis (3). Recommended Applications WB, IHC, ICC Applications and Recommended Dilution Factors WB: 1:1,000 - 10,000 IHC: 1:50 - 100 ICC: 1:50 Species Reactivity Human Products Data Western blot analysis on SH-SY5Ycell lysates using anti-FE65 RabMAb (cat. #2660-1). Immunohistochemical analysis of paraffin-embedded human brain tissue using anti-FE65 RabMAb (cat. #2660-1). Specificity A synthetic peptide corresponding to residues in human FE65 was used as an immunogen. |
| 性狀 | 【反應(yīng)特異性】Human
【克隆 ID】EPR3538 【用途】WB , IHC , ICC 【抗原分子量】100kDa |
| 貯存 | Storage Condition and Buffer Store at -20 °C. Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt. |
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