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JNK1 Phospho (pT183) / JNK2 Phospho (pT183) / JNK3 Phospho (pT221) (MAPK10)
英文名：MAPK10 antibody
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| 貨號 | 規格 | 貨期 | 庫存 | 價格 | 促銷價 | 訂購 |
| 1308114471-100ul | 現貨 | 0 | ￥0 |
| 別 名 | MAPK10 antibody, FLJ12099 antibody, FLJ33785 antibody, JNK3 antibody, JNK3A antibody, MGC50974 antibody, PRKM10 antibody, p493F12 antibody, p54bSAPK antibody, Mitogen-activated protein kinase 10 antibody, MAP kinase p49 3F12 antibody, Stress-activated pro |
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| 產品參數 | 【產品介紹】C-Jun N-terminal kinases (JNK) are
distantly related to mitogen-activated protein kinases (ERKs) and are activated by dual phosphorylation on Tyr and Thr. The JNK protein kinase group consists of three isoforms (JNK1, 2, and 3) and regulates transcription activity of the AP-1 complex, and release and regulation of cytochome c (1). JNK becomes activated in vivo in response to pro-inflammatory cytokines or cellular stresses. Its full activation requires the phosphorylation of a threonine and a tyrosine residue in a Thr-Pro-Tyr motif, which can be catalysed by the protein kinases mitogen-activated protein kinase kinase MKK4 and MKK7 (2). Unlike other JNK isoforms, JNK3 is only expressed in the heart and nervous system. JNK3 has been implicated in stress-induced neuronal apoptosis (3). Recommended Applications WB, IHC, ICC, IP Applications and Recommended Dilution Factors WB: 1:1,000 - 10,000 IHC: 1:100 - 250 ICC: 1:50 - 100 IP: 1:10 - 100 Species Reactivity * Human, Mouse, Rat *Species cross-reactivity is based on WB analysis Products Data Western blot analysis on NIH/3T3 cell lysates using anti-Phospho-JNK1 (pT183) / JNK2 (pT183) / JNK3 (pT221) RabMAb (cat. #3893-1). Cells were either (A) untreated (B) treated with Anisomycin. Immunohistochemical analysis of paraffin-embedded human brain tissue using anti-Phospho-JNK1 (pT183) / JNK2 (pT183) / JNK3 (pT221) RabMAb (cat. #3893-1). Specificity A synthetic phospho-peptide corresponding to residues surrounding threonine 221 of human JNK3 was used as immunogen. The antibody will detect JNK1 (pT183), JNK2(pT183) and JNK3 (pT221). |
| 性狀 | 【產品類型】Rabbit Monoclonal Antibody
【反應特異性】Human , Mouse , Rat 【克隆 ID】EPR5693 【用途】WB , IHC , ICC , IP 【產品性狀】 【陽性對照】 【產品濃度】 【細胞定位】 【抗原分子量】46 - 54kDa |
| 貯存 | Store at -20° C. Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt. |
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