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Recombinant Human Tumor Necrosis Factor-alpha/TNFSF2
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檢測信息查詢
| 貨號 | 規格 | 貨期 | 庫存 | 價格 | 促銷價 | 訂購 |
| 1308132582-10 μg | 0 | ￥3800 | ||||
| 1308132582-50 μg | 0 | ￥5900 |
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| 性狀 | Recombinant Human Tumor Necrosis Factor-alpha/TNFSF2 是一種促炎性細胞因子，同時能夠高效地靶作用于腫瘤細胞，而對正常細胞毒性很低。
Synonyms rHuTNF-α/TNFSF2; TNF-alpha; Cachectin; DIF; TNFA; Differentiation-inducing factor ; 重組人腫瘤壞死因子-α/TNFSF2 Species Human Source E. coli Accession P01375 Gene ID 7124 Molecular Weight Approximately 17.3 kDa AA Sequence VRSSSRTPSD KPVAHVVANP QAEGQLQWLN RRANALLANG VELRDNQLVV PSEGLYLIYS QVLFKGQGCP STHVLLTHTI SRIAVSYQTK VNLLSAIKSP CQRETPEGAE AKPWYEPIYL GGVFQLEKGD RLSAEINRPD YLDFAESGQV YFGIIAL Biological Activity The ED50 is <30 pg/mL as measured by L-929 mouse fibrosarcoma cells, corresponding to a specific activity of >3.3 × 107 units/mg. Appearance Lyophilized powder. Formulation Lyophilized after extensive dialysis against PBS. Endotoxin Level <0.2 EU/μg, determined by LAL method. Reconstitution Reconstitute the lyophilized recombinant Human Tumor Necrosis Factor-alpha/TNFSF2 (rHuTNF-α/TNFSF2) to 100 μg/mL using ddH2O or diluted with PBS. Storage & Stability Lyophilized recombinant Human Tumor Necrosis Factor-alpha/TNFSF2 (rHuTNF-α/TNFSF2) is stored at -20°C. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage. Shipping Room temperature in continental US; may vary elsewhere. Background Tumor necrosis factor α (TNF-α, also known as cachectin) is a strong pro-inflammatory cytokine playing an important role in the immune system during inflammation, cell proliferation, differentiation and apoptosis. TNF-α is type II transmembrane protein that can be expressed in both membrane-bound and secreted forms. Receptors for TNF-a are part of TNF receptor (TNFR) superfamily, with characteristic intracellular segment, a transmembrane domain, and an extracellular ligand-binding domain. They are type I transmembrane glycoproteins characterized by a cysteinerich motif (up to 40 aminoacids) repeated 2-6 times in the extracellular N-terminal domain[1]. Tumor necrosis factor-α (TNF-α) is a pleiotropic factor exhibiting antitumor effects, alters endothelial barrier function, reduces tumor interstitial pressure and mediates immune responses. TNF-α is associated with a number of cell signalling events, associated with cell necrosis and apoptosis, and is important for resistance to infection and cancer[2] |
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