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Recombinant Mouse Granulocyte-Macrophage Colony Stimulating Factor (CHO-expressed)
英文名：
Cas號(hào)：
Cas號(hào)：
檢測(cè)信息查詢
| 貨號(hào) | 規(guī)格 | 貨期 | 庫(kù)存 | 價(jià)格 | 促銷(xiāo)價(jià) | 訂購(gòu) |
| 1308132593-10 μg | 0 | ￥4200 | ||||
| 1308132593-50 μg | 0 | ￥8400 |
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| 性狀 | Recombinant Mouse Granulocyte-Macrophage Colony Stimulating Factor (CHO-expressed) 是造血生長(zhǎng)因子和免疫調(diào)節(jié)劑。
Synonyms rMuGM-CSF; CSF-2; MGI-1GM; Pluripoietin-alpha; Molgramostin; Sargramostim Species Mouse Source CHO Accession P01587 Gene ID 12981 Molecular Weight 15-19 kDa AA Sequence APTRSPITVT RPWKHVEAIK EALNLLDDMP VTLNEEVEVV SNEFSFKKLT CVQTRLKIFE QGLRGNFTKL KGALNMTASY YQTYCPPTPE TDCETQVTTY ADFIDSLKTF LTDIPFECKK PVQK Biological Activity The ED50 is <0.05 ng/mL as measured by mouse FDC-P1 cells, corresponding to a specific activity of >2 × 107 units/mg. Appearance Lyophilized powder. Formulation Lyophilized after extensive dialysis against PBS. Endotoxin Level <0.2 EU/μg, determined by LAL method. Reconstitution Reconstitute the lyophilized recombinant Murine Granulocyte-Macrophage Colony Stimulating Factor (CHO-expressed) (rMuGM-CSF) to 100 μg/mL using ddH2O or diluted with PBS. Storage & Stability Lyophilized recombinant Murine Granulocyte-Macrophage Colony Stimulating Factor (CHO-expressed) (rMuGM-CSF) is stored at -20°C. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage. Shipping Room temperature in continental US; may vary elsewhere. Background Granulocyte-macrophage colony-stimulating factor (GM-CSF) is produced by a variety of cell types including T cells, macrophages, endothelial cells and fibroblasts upon receiving immune stimuli. It is an important hematopoietic growth factor and immune modulator. GM-CSF also has profound effects on the functional activities of various circulating leukocytes. GM-CSF stimulates multipotent progenitor cells depending on its concentration, the proliferation of macrophage progenitors at the lowest doses, followed by granulocyte, erythroid, eosinophil, megakaryocyte and multipotent progenitors. It also stimulates the differentiation of myeloid leukemic cells and controls eosinophil function in some instances[1][2]. GM-CSF also enhances the functionality of mature cells, such as neutrophils. In neutrophils, GM-CSF potentiates degranulation, the release of oxygen and nitrogen radical ions, phagocytosis, and inhibits apoptosis[3]. GM-CSF inhibition in some animal models of autoimmune diseases showed significant beneficial effects[4]. GM-CSF also has many pro-inflammatory functions and recent data implicates GM-CSF as a key factor in Th17 driven autoimmune inflammatory conditions[5]. |
| 貯存 |
- 順-2-已烯 7688-21-3
- Recombinant Mouse Basic Fibroblast Growth Factor
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- Recombinant Mouse Granulocyte Colony-stimulating Factor (CHO-expressed)
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- Recombinant Mouse Insulin-like Growth factor-1
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