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Recombinant Rat Macrophage-Colony Stimulating Factor (CHO-expressed)
英文名：
Cas號(hào)：
Cas號(hào)：
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| 貨號(hào) | 規(guī)格 | 貨期 | 庫(kù)存 | 價(jià)格 | 促銷價(jià) | 訂購(gòu) |
| 1308132758-10 μg | 0 | ￥4200 | ||||
| 1308132758-50 μg | 0 | ￥12200 |
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| 性狀 | Recombinant Rat Macrophage-Colony Stimulating Factor (CHO-expressed)是一種促炎細(xì)胞因子，其與其受體CSF1R結(jié)合，參與單核細(xì)胞/巨噬細(xì)胞譜系細(xì)胞的發(fā)育和增殖，并參與破骨細(xì)胞的誘導(dǎo)。
Synonyms rRtM-CSF; CSF1; MCSF ; 重組大鼠巨噬細(xì)胞集落刺激因子 (CHO表達(dá)) Species Rat Source CHO Accession Q8JZQ0 Gene ID 78965 Molecular Weight 32-40 kDa AA Sequence EVSEHCSHMI GNGHLQILQQ LIDSQMETAC LIEYKFVDQE QLDDPVCYLK KAFVLVQVII EETMRFKDNT PNANATERLQ ELSMKLNSCF IKDYKEQNEA CVQTYKESPL RLLEKIKNFF NETKNFLEKD WNIFSKNCND SFAKCSSRDV VTKP Biological Activity The ED50 is <2.5 ng/mL as measured by murine M-NFS-60 cells, corresponding to a specific activity of >4.0 × 105 units/mg. Appearance Lyophilized powder. Formulation Lyophilized after extensive dialysis against PBS. Endotoxin Level <0.2 EU/μg, determined by LAL method. Reconstitution Reconstitute the lyophilized recombinant Rat Macrophage-Colony Stimulating Factor (CHO-expressed) (rRtM-CSF) to 100 μg/mL using ddH2O or PBS. Storage & Stability Lyophilized recombinant Rat Macrophage-Colony Stimulating Factor (CHO-expressed) (rRtM-CSF) is stored at -20°C. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage. Shipping Room temperature in continental US; may vary elsewhere. Background Macrophage Colony Stimulating Factor (M-CSF) is a pro-inflammatory cytokine, constitutively produced by several cell types, such as fibroblasts, endothelial cells, stromal cells, macrophages, smooth muscle cells and osteoblasts, binds to its receptor CSF1R, and exists in several isoforms- as a secreted glycoprotein, a cell-surface protein and a proteoglycan[1]. M-CSF is involved in the development and proliferation of cells of the monocyte/macrophage lineage and participates in the induction of osteoclasts, which are important in the destruction of bone and cartilage and in the periarticular osteoporotic changes seen in patients with rheumatoid arthritis[2]. |
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