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Recombinant Human Fibroblast Growth Factor 21, His (CHO-expressed)
英文名：
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檢測信息查詢
| 貨號 | 規(guī)格 | 貨期 | 庫存 | 價格 | 促銷價 | 訂購 |
| 1308132858-10 μg | 0 | ￥3200 | ||||
| 1308132858-50 μg | 0 | ￥7800 |
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| 性狀 | Recombinant Human Fibroblast Growth Factor 21, His (CHO-expressed) 是 CHO 細胞中產(chǎn)生的 C-末端含 His 標簽的多肽鏈。是一種成纖維細胞生長因子 (FGF)，可作為代謝調(diào)節(jié)劑，具有多重效應(yīng)。
Synonyms rHuFGF-21, His; FGF21 Species Human Source CHO Accession Q9NSA1 Gene ID 26291 Molecular Weight 23-25 kDa AA Sequence HPIPDSSPLL QFGGQVRQRY LYTDDAQQTE AHLEIREDGT VGGAADQSPE SLLQLKALKP GVIQILGVKT SRFLCQRPDG ALYGSLHFDP EACSFRELLL EDGYNVYQSE AHGLPLHLPG NKSPHRDPAP RGPARFLPLP GLPPALPEPP GILAPQPPDV GSSDPLSMVG PSQGRSPSYA SHHHHHH Biological Activity The ED50 is <0.3 μg/mL as measured by NIH-3T3 cells. Appearance Lyophilized powder. Formulation Lyophilized after extensive dialysis against PBS. Endotoxin Level <0.2 EU/μg, determined by LAL method. Reconstitution Reconstitute the lyophilized recombinant Human Fibroblast Growth Factor 21, His (CHO-expressed) (rHuFGF-21, His) to 100 μg/mL using ddH2O or diluted with PBS. Storage & Stability Lyophilized recombinant Human Fibroblast Growth Factor 21, His (CHO-expressed) (rHuFGF-21, His) is stored at -20°C. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage. Shipping Room temperature in continental US; may vary elsewhere. Background Human Fibroblast Growth Factor 21 (FGF21) acts in an endocrine mannerand and is a metabolic regulator with pleiotropic effects. FGF21 possesses protective effects in the cardiovascular system, primarily due to metabolic effects other thanmaintaining energy homoeostasis. FGF21 is also involved inseveral processes, including reducing arteriosclerotic plaque formation in major vessels and protecting themyocardium from injuries caused by infarction, ischaemia-reperfusion, isoproterenol-induced hypertrophy anddiabetic lipotoxicity. In addition, FG2F1 induces these effects by atten-uating remodelling-related in?ammation and oxidativestress and promoting myocardial energy metabolism, as well as by preventing lipid- or diabetes-induced cardiaccell apoptosis. FGF21 functions via its interaction with FGF receptors (FGFRs), with the assistance of the co-receptor β-Klotho. Structurally, the FGFRs are divided into four isoforms, FGFR1-FGFR4[1]. |
| 貯存 |
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- Recombinant Human Fibroblast Growth Factor 21, His (CHO-expressed)
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