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GRP170 / ORP150 (HYOU1)
英文名：GRP170 / ORP150 (HYOU1)
Cas號：
Cas號：
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| 貨號 | 規格 | 貨期 | 庫存 | 價格 | 促銷價 | 訂購 |
| 1308114382-100ul | 現貨 | 0 | ￥0 |
| 別 名 | HYOU1 antibody, DKFZp686N08236 antibody, FLJ94899 antibody, FLJ97572 antibody, Grp170 antibody, HSP12A antibody, ORP150 antibody, Hypoxia up-regulated protein 1 antibody, 170 kDa glucose-regulated protein antibody |
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| 產品參數 | 【產品介紹】GRP170 / ORP150 belongs to the heat
shock protein 70 family. It uses alternative transcription start sites. A cis-acting segment found in the 5' UTR is involved in stress-dependent induction, resulting in the accumulation of this protein in the endoplasmic reticulum (ER) under hypoxic conditions. GRP170 / ORP150 is thought to play an important role in protein folding and secretion in the ER. Since suppression of the protein is associated with accelerated apoptosis, it is also suggested to have an important cytoprotective role in hypoxia-induced cellular perturbation. This protein has been shown to be up-regulated in tumors, especially in breast tumors, and thus it is associated with tumor invasiveness. GRP170 / ORP150 also has an alternative translation initiation site, resulting in a protein that lacks the N-terminal signal peptide. This signal peptide-lacking protein, which is only 3 amino acids shorter than the mature protein in the ER, is thought to have a housekeeping function in the cytosol. In rat, this protein localizes to both the ER by a carboxy-terminal peptide sequence and mitochondria by an amino-terminal targeting signal (1). Recommended Applications WB, IHC, FC Applications and Recommended Dilution Factors WB: 1:1,000 - 10,000 IHC: 1:250 - 500 FC: 1:10 - 100 Species Reactivity * Human, Mouse, Rat *Species cross-reactivity is based on WB analysis Products Data Western blot analysis on (A) fetal liver, (B) rat liver, (C) rat pancreas, (D) 293T, (E) MCF-7, (F) MDA-MB-435S, (G) SH-SY5Y, and (H) HeLa lysates using anti-GRP170 / ORP150 RabMAb (cat. #3905-1). Immunohistochemical analysis of paraffin-embedded human liver tissue using anti-GRP170 / ORP150 RabMAb (cat. #3905-1). Specificity A synthetic peptide corresponding to residues in human GRP170 / ORP150 was used as an immunogen. |
| 性狀 | 【產品類型】Rabbit Monoclonal Antibody
【反應特異性】Human , Mouse , Rat 【克隆 ID】EPR5890 【用途】WB , IHC , FC 【產品性狀】 【陽性對照】 【產品濃度】 【細胞定位】 【抗原分子量】150kDa |
| 貯存 | Store at -20° C. Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt. |
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