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HER2 / ErbB2 Phospho (pY877) (ERBB2)
英文名：HER2 / ErbB2 Phospho (pY877) (ERBB2)
Cas號：
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| 貨號 | 規(guī)格 | 貨期 | 庫存 | 價格 | 促銷價 | 訂購 |
| 1308114389-100ul | 現(xiàn)貨 | 0 | ￥0 |
| 別 名 | ERBB2 antibody, CD340 antibody, HER-2 antibody, HER-2/neu antibody, HER2 antibody, MLN 19 antibody, NEU antibody, NGL antibody, TKR1 antibody, Receptor tyrosine-protein kinase erbB-2 antibody, Proto-oncogene Neu antibody, Proto-oncogene c-ErbB-2 antibody, |
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| 產品參數(shù) | 【產品介紹】HER2 / ErbB2 is one of the four members of
the ErbB receptor family of transmembrane receptor- like tyrosine kinases (1). The kinase activity of ErbB2 can be activated without ligand if it is overexpressed, and by association with other ErbB proteins (2). Overexpression of ErbB2 is detected in almost 40% of human breast cancers (3). ErbB2 is one of the major targets for the treatment of breast cancer and other carcinomas. Autophosphorylation did not modulate receptor turnover. A Tyr----Phe substitution of ErbB-2 Tyr-877 homologous to pp60c-src Tyr-416 did not alter ErbB-2 biological and biochemical properties, thus excluding the possibility that phosphorylation of this residue, located in the kinase domain, modulates ErbB-2 gp185 catalytic function (4). Recommended Applications WB, IHC, ICC Applications and Recommended Dilution Factors WB: 1:500 - 1000 IHC: 1:250 - 500 ICC: 1:50 - 100 Species Reactivity Human Products Data Western blot analysis on (A,B) HeLa cell lysates or (C,D) SKBR-3 using anti-Phospho-HER2 (pY877) RabMAb (Cat. #2521-1) Cells were either (A,C) untreated (B,D) treated with EGF Paraffin-embedded human breast ductal infiltrating carcinoma tissue stained with anti-HER2 Phospho (pY877) RabMAb. (Cat# 2521-1) Note positive (3+) membrane staining of tumor cells Immunofluorescent staining of SKBR3 cells using anti-HER2 Phospho (pY877) RabMAb. (Cat# 2521-1). Specificity A phospho - specific peptide corresponding to residues surrounding tyrosine 877 of human HER2 was used as an immunogen. This antibody detects HER2 phosphorylated at tyrosine 877. |
| 性狀 | 【產品類型】Rabbit Monoclonal Antibody
【反應特異性】Human 【克隆 ID】EP2324Y 【用途】WB , IHC , ICC 【產品性狀】 【陽性對照】 【產品濃度】 【細胞定位】 【抗原分子量】180kDa |
| 貯存 | Store at -20 °C. Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt. |
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