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Recombinant Rat MCP-1/CCL2 (HEK293-expressed)
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| 性狀 | Recombinant Rat MCP-1/CCL2 (HEK293-expressed) 是屬于CC趨化因子家族的細(xì)胞因子。
Synonyms rRtMCP-1/CCL2; C-C motif chemokine 2; MCAF; MCP-1; SCYA2 ; 重組大鼠MCP-1/CCL2 (HEK293-表達(dá)) Species Rat Source HEK 293 Accession P14844 Gene ID 24770 Molecular Weight 10-15 kDa AA Sequence QPDAVNAPLT CCYSFTGKMI PMSRLENYKR ITSSRCPKEA VVFVTKLKRE ICADPNKEWV QKYIRKLDQN QVRSETTVFY KIASTLRTSA PLNVNLTHKS EANASTLFST TTSSTSVEVT SMTEN Biological Activity The ED50 is <0.3 μg/mL as measured by CHO-K1/Gα15/rCCR2 cells (human Gα15 and rat CCR2 stably expressed in CHO-K1 cells). Appearance Lyophilized powder. Formulation Lyophilized after extensive dialysis against PBS. Endotoxin Level <0.2 EU/μg, determined by LAL method. Reconstitution Reconstitute the lyophilized recombinant Rat MCP-1/CCL2 (HEK293-expressed) (rRtMCP-1/CCL2) to 100 μg/mL using ddH2O or PBS. Storage & Stability Lyophilized recombinant Rat MCP-1/CCL2 (HEK293-expressed) (rRtMCP-1/CCL2) is stored at -20°C. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage. Shipping Room temperature in continental US; may vary elsewhere. Background CCL2 is produced by a variety of cell types, either constitutively or after induction by oxidative stress, cytokines, or growth factors. CCL2 is produced by many cell types, including endothelial, fibroblasts, epithelial, smooth muscle, mesangial, astrocytic, monocytic, and microglial cells. CCL2 regulates the migration and infiltration of monocytes, memory T lymphocytes, and natural killer (NK) cells[1]. The chemokine CCL2 and its main chemokine receptor CCR2 have been implicated in the pathogenesis of several different disease processes, including vascular permeability and attraction of immune cells during metastasis, a number of different neurological disorders, autoimmune disease, obesity, and atherosclerosis[2]. |
| 貯存 |
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