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Recombinant Human TWEAK (CHO-expressed)
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| 性狀 | Recombinant Human TWEAK (CHO-expressed) 可以通過多種特異性的細(xì)胞死亡通路來誘導(dǎo)凋亡，并能促進(jìn)內(nèi)皮細(xì)胞的增值和遷移，從而調(diào)節(jié)血管生成。
Synonyms rHuTWEAK; TNF-related weak inducer of apoptosis; TNFSF12; DR3LG; APO3L ; 重組人腫瘤壞死因子配體超家族成員12 Species Human Source CHO Accession O43508 Gene ID 8742 Molecular Weight 20-22 kDa AA Sequence RKTRARRAIA AHYEVHPRPG QDGAQAGVDG TVSGWEEARI NSSSPLRYNR QIGEFIVTRA GLYYLYCQVH FDEGKAVYLK LDLLVDGVLA LRCLEEFSAT AASSLGPQLR LCQVSGLLAL RPGSSLRIRT LPWAHLKAAP FLTYFGLFQV H Biological Activity The ED50 is <1 ng/mL as measured by HTB-38 (HT-29) cells. Appearance Lyophilized powder. Formulation Lyophilized after extensive dialysis against PBS. Endotoxin Level <0.2 EU/μg, determined by LAL method. Reconstitution Reconstitute the lyophilized recombinant Human TWEAK (CHO-expressed) (rHuTWEAK) to 100 μg/mL using ddH2O or PBS. Storage & Stability Lyophilized recombinant Human TWEAK (CHO-expressed) (rHuTWEAK) is stored at -20°C. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage. Shipping Room temperature in continental US; may vary elsewhere. Background TWEAK is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. TWEAK is a ligand for the FN14/TWEAKR receptor. TWEAK has overlapping signaling functions with TNF, but displays a much wider tissue distribution. Leukocytes are the main source of TWEAK including human resting and activated monocytes, dendritic cells and natural killer cells[1]. TWEAK can induce apoptosis via multiple pathways of cell death in a cell type-specific manner. This cytokine is also found to promote proliferation and migration of endothelial cells, and thus acts as a regulator of angiogenesis[2]. |
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