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Recombinant Human CD47, Fc Chimera (HEK293-expressed)
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檢測信息查詢
| 貨號 | 規格 | 貨期 | 庫存 | 價格 | 促銷價 | 訂購 |
| 1308132848-10 μg | 0 | ￥2400 | ||||
| 1308132848-50 μg | 0 | ￥6400 |
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| 性狀 | Recombinant Human CD47, Fc Chimera (HEK293-expressed) 是在 HEK293 中產生的 C-末端標記 IgG1 Fc 片段的多肽鏈。CD47 是癌癥免疫療法的重要靶標。
Synonyms rHuCD47, Fc Chimera; MER6; IAP; OA3 Species Human Source HEK 293 Accession Q08722 Gene ID 961 Molecular Weight 60-65 kDa AA Sequence QLLFNKTKSV EFTFCNDTVV IPCFVTNMEA QNTTEVYVKW KFKGRDIYTF DGALNKSTVP TDFSSAKIEV SQLLKGDASL KMDKSDAVSH TGNYTCEVTE LTREGETIIE LKYRVVSWFS P Biological Activity 2 μg/mL (100 μL/well) of immoblized recombinant human SIRPa-His can bind human CD47-Fc with a linear range of 0.25-185 ng/mL. Appearance Lyophilized powder. Formulation Lyophilized after extensive dialysis against PBS. Endotoxin Level <0.2 EU/μg, determined by LAL method. Reconstitution Reconstitute the lyophilized recombinant Human CD47, Fc Chimera (HEK293-expressed) (rHuCD47, Fc Chimera) to 100 μg/mL using ddH2O or diluted with PBS. Storage & Stability Lyophilized recombinant Human CD47, Fc Chimera (HEK293-expressed) (rHuCD47, Fc Chimera) is stored at -20°C. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage. Shipping Room temperature in continental US; may vary elsewhere. Background Targeting CD47 is in the spotlight of cancer immunotherapy. Blocking CD47 triggers the recognition and elimination of cancer cells by the innate immunity. The CD47/SIRP-α axis has been established as an important regulator of innate anti-cancer immunity, with many if not all malignancies overexpressing the receptor CD47 that binds to phagocyte-expressed SIRP-α[1]. |
| 貯存 |
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- Recombinant Human CD47, Fc Chimera (HEK293-expressed)
- Recombinant Human CD47, His (HEK293-expressed)
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