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Recombinant Human CD19, Fc Chimera (CHO-expressed)
英文名：
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| 貨號 | 規格 | 貨期 | 庫存 | 價格 | 促銷價 | 訂購 |
| 1308132846-10 μg | 0 | ￥3800 | ||||
| 1308132846-50 μg | 0 | ￥8400 |
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| 性狀 | Recombinant Human CD19, Fc Chimera (CHO-expressed) 是在 CHO 中產生的 C-末端標記 IgG1 Fc 片段的多肽鏈。CD19 是正常和腫瘤 B 細胞的生物標志物。
Synonyms rHuCD19, Fc Chimera; B-lymphocyte surface antigen B4; T-cell surface antigen Leu-12 Species Human Source CHO Accession P15391 Gene ID 930 Molecular Weight Approximately 62 kDa AA Sequence PEEPLVVKVE EGDNAVLQCL KGTSDGPTQQ LTWSRESPLK PFLKLSLGLP GLGIHMRPLA IWLFIFNVSQ QMGGFYLCQP GPPSEKAWQP GWTVNVEGSG ELFRWNVSDL GGLGCGLKNR SSEGPSSPSG KLMSPKLYVW AKDRPEIWEG EPPCLPPRDS LNQSLSQDLT MAPGSTLWLS CGVPPDSVSR GPLSWTHVHP KGPKSLLSLE LKDDRPARDM WVMETGLLLP RATAQDAGKY YCHRGNLTMS FHLEITARPV LWHWLLRTGG WK Appearance Lyophilized powder. Formulation Lyophilized after extensive dialysis against PBS. Endotoxin Level <0.2 EU/μg, determined by LAL method. Reconstitution Reconstitute the lyophilized recombinant Human CD19, Fc Chimera (CHO-expressed) (rHuCD19, Fc Chimera) to 100 μg/mL using ddH2O or diluted with PBS. Storage & Stability Lyophilized recombinant Human CD19, Fc Chimera (CHO-expressed) (rHuCD19, Fc Chimera) is stored at -20°C. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage. Shipping Room temperature in continental US; may vary elsewhere. Background CD19 is classified as a type I transmembrane protein, with a single transmembrane domain, a cytoplasmic C-terminus, and extracellular N-terminus. CD19 is a biomarker for normal and neoplastic B cells, as well as follicular dendritic cells. CD19 is critically involved in establishing intrinsic B cell signaling thresholds through modulating both B cell receptor-dependent and independent signaling. CD19 functions as the dominant signaling component of a multimolecular complex on the surface of mature B cells, alongside complement receptor CD21, and the tetraspanin membrane protein CD81 (TAPA-1), as well as CD225. Through study of CD19 transgenic and knockout mouse models, it becomes clear that CD19 plays a critical role in maintaining the balance between humoral, antigen-induced response and tolerance induction[1]. |
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