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EGFR Phospho (pT678)
英文名：Rabbit Monoclonal Antibody
Cas號(hào)：
Cas號(hào)：
檢測(cè)信息查詢(xún)
| 貨號(hào) | 規(guī)格 | 貨期 | 庫(kù)存 | 價(jià)格 | 促銷(xiāo)價(jià) | 訂購(gòu) |
| 1308113540-100ul | 現(xiàn)貨 | 0 | ￥0 |
| 別 名 | EGFR antibody, ERBB antibody, ERBB1 antibody, HER1 antibody, PIG61 antibody, mENA antibody, Epidermal growth factor receptor antibody, Proto-oncogene c-ErbB-1 antibody, Receptor tyrosine-protein kinase erbB-1 antibody |
| Cas號(hào) | |
| M D L | |
| 分子式 | |
| 分子量 | |
| 產(chǎn)品參數(shù) | 【產(chǎn)品介紹】Epidermal growth factor receptor (EGFR) is a
175 kDa transmembrane glycoprotein receptor tyrosine kinase that, activated by epidermal growth factor (EGF), affects cell growth and differentiation (1). Binding of EGF or TGF alpha to EGFR activates tyrosine kinase activity of the receptor (2). The epidermal growth factor (EGF) receptor is regulated by EGF-stimulated autophosphorylation and by phorbol ester-stimulated, protein kinase C (Ca2+/ phospholipid-dependent enzyme) mediated phosphorylation at identified sites. The EGF receptor contains additional phosphorylation sites including a prominent phosphothreonine and several phosphoserines which account for the majority of phosphate covalently bound to the receptor in vivo. Analysis of predicted secondary structure of the EGF receptor reveals that all of the phosphorylation sites are located near beta turns (3). Recommended Applications WB, ICC Applications and Recommended Dilution Factors WB: 1:1,000 - 10,000 ICC: 1:100 - 250 Species Reactivity * Human *Cross reactivity determined by western blot only. Products Data A. Western blot analysis on A431 cell lysates using anti-Phospho-EGFR (pT678) RabMAb (cat. #2344-1), 1:50,000 dilution. Cells were either (A) untreated (B) treated with EGF B. Immunofluorescent staining of A431 cells using anti-Phospho-EGFR RabMAb (cat. # 2344-1). Specificity A phospho specific peptide corresponding to residues surrounding threonine 678 of human EGFR was used as an immunogen. This antibody detects EGFR phosphorylated on thr678. |
| 性狀 | 【反應(yīng)特異性】Human
【克隆 ID】EP2255Y 【用途】WB , ICC 【抗原分子量】175kDa |
| 貯存 | Storage Condition and Buffer Store at -20 °C. Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt. |
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