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HSD17B1 (C-term)
英文名：HSD17B1 (C-term)
Cas號(hào)：
Cas號(hào)：
檢測(cè)信息查詢
| 貨號(hào) | 規(guī)格 | 貨期 | 庫存 | 價(jià)格 | 促銷價(jià) | 訂購 |
| 1308114417-100ul | 現(xiàn)貨 | 0 | ￥0 |
| 別 名 | HSD17B1 antibody, EDH17B2 antibody, EDHB17 antibody, HSD17 antibody, MGC138140 antibody, SDR28C1 antibody, Estradiol 17-beta-dehydrogenase 1 antibody, E2DH antibody, Placental 17-beta-hydroxysteroid dehydrogenase antibody |
| Cas號(hào) | |
| M D L | |
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| 分子量 | |
| 產(chǎn)品參數(shù) | 【產(chǎn)品介紹】The principal human estrogen, 17 beta-
estradiol, is a potent stimulator of certain endocrine-dependent forms of breast cancer. Because human estrogenic 17 beta-hydroxysteroid dehydrogenase (HSD17B1) catalyzes the last step in the biosynthesis of 17 beta-estradiol from the less potent estrogen, estrone, it is an attractive target for the design of inhibitors of estrogen production and tumor growth (1). It is concluded that the steroid-binding site of human placental HSD17B1 contains a histidine residue which proximates the upper A-ring region of the steroid as it undergoes the reversible binding step (2). Human estrogenic HSD17B1 is an NADP(H)-preferring enzyme. It possesses 11- and 4-fold higher specificity toward NADP(H) over NAD(H) for oxidation and reduction, respectively, as demonstrated by kinetic studies (3). Defects in the conversion of androstenedione to testosterone in the fetal testes by the enzyme HSD17B1 give rise to genetic males with female external genitalia (4) Recommended Applications WB, IHC, ICC, FC Applications and Recommended Dilution Factors WB: 1:500 IHC: 1: 100 - 250 ICC: 1:50 FC: 1:40 Species Reactivity * Human *Cross reactivity determined by western blot only. Products Data A. Western blot analysis on human placenta lysate using anti-HSD17B1 RabMAb (cat. # 2127-1), dilution 1:500. Immunohistochemical analysis of paraffin-embedded human placenta tissue using anti-HSD17B1 RabMAb (cat.# 2127-1). Specificity A synthetic peptide corresponding to residues on the C-terminus of human HSD17B1 was used as an immunogen. |
| 性狀 | 【產(chǎn)品類型】Rabbit Monoclonal Antibody
【反應(yīng)特異性】Human 【克隆 ID】EP1681Y 【用途】WB , IHC , ICC , FC 【產(chǎn)品性狀】 【陽性對(duì)照】 【產(chǎn)品濃度】 【細(xì)胞定位】 【抗原分子量】35kDa |
| 貯存 | Store at -20 °C. 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt. |
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